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Furthermore, aloe-emodin exhibits anti-cancer activity against NSCLC (A549 and NCI-H1299) through Caspase-dependent apoptosis, autophagy induction via MAPK activation and AKT/mTOR inhibition, and ROS-mediated autophagy-triggered apoptosis, demonstrating its potential as a therapeutic candidate and synergize with gemcitabine [505]

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It is estimated to impact around 5-15% of women in their reproductive years ( In 1925, Sampson first outlined the diagnostic criteria for EAOC ( 2 Pathogenesis of EAOC 2.1 Abnormal expression of related genes Multiple studies suggest that ARID1A may act as a tumor suppressor ( Furthermore, the lack of p53 has been observed to lead to an exaggerated proliferation of endometrial glands ( Multiple studies have provided evidence of an increase in the copy number of the CCNE1 gene and an up-regulation of CCNE1 in ovarian clear cell carcinoma

[DOI] [PubMed] [Google Scholar] 115.Higdon J.V., Delage B., Williams D.E., Dashwood R.H

BTZ induces mitochondrial morphological abnormalities in the peripheral nervous system (PNS) (Zheng et al., 2012)

Researchers have also explored DSIPs possible role in stress regulation, hormone signaling, and pain modulation, but the overall evidence remains preliminary and insufficient for definitive clinical recommendations