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Statistics The recorded data (1 min bins) and derived parameters, Vt/Ti and Response Area (cumulative percent changes from pre-values) were taken for statistical analyses

New long-term use was defined as having Schedule II opioid analgesic prescriptions covering at least 70 days' supply over the 3 months prior to study entry and none during the preceding 6 months

Glutathione metabolism is altered before symptoms appear In our model, altered energy metabolism at 3 months was concomitant with altered glutathione metabolism selectively in the iSPN + mut