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Vitamin B12 is essential for red blood cell production, nerve function, energy metabolism and the synthesis of DNA

demonstrated that elevated tumor redox scores directly downregulate STING and MDA5 pathways, thereby suppressing type I interferon signaling and enforcing an immunologically cold microenvironment [306]

482 Given that hepatocytes are only one of the sources of eNAMPT, circulating NAMPT levels may not represent its actually concentration in local liver or adipose tissues, thus requiring further research to determine its exact role in NAFLD