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This seems counterintuitive, but degraded peptides can produce different side effect profiles

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coli that are more invasive, aggregative, pathogenic, hemorrhagic and toxigenic can adhere to the intestinal epithelium and trigger an immune response (Rossi et al., 2018)

In pyruvate kinase deficiency, there is ineffective erythropoiesis together with chronic hemolysis, leading to iron-loading anemia (Mojzikova et al., 2014)

Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency