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Cigarette smoke exposure does not activate NUPR1 in phBECs CS is the most important risk factor for chronic lung disease 42

The mean incidence of all HPAs detected by newborn screening (NBS) programmes in Europe is estimated to be approximately 1:10000 [5], and BH 4 deficiencies are presumed to constitute around 12% of these cases

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It accelerates the process of neurogenesis and angiogenesis, which are critical for repairing brain damage and restoring function after a stroke

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