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These technologies enable a more precise understanding of how ferroptosis contributes to neurovascular dysfunction, cognitive decline, and treatment responses in VCID patients

Notably, the expression of inducible costimulatory molecules (ICOS) on CD4 + T cells is significantly increased in the inflammatory mucosa of IBD patients, and this overexpression promotes the production of inflammatory cytokines such as IL-5 in UC and IFN- in CD, suggesting that ICOS may serve as a potential therapeutic target for IBD [40]

Consequently, with aging, there is an increased susceptibility to the inflammatory process, resulting in greater neurodegeneration associated with elevated intraocular pressure (IOP) that occurs in glaucoma

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