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People who live in areas with low levels of selenium or iodine, where a baseline shortage increases response because resolving baseline deficits can enhance antioxidant selenium enzyme activity (selenium), restore thyroid hormone synthesis and metabolism (iodine), and possibly lower thyroid autoimmunityas a result, effect sizes may seem larger in deficient settings than in replete populations [2,18,36,47]

It's because hydrolyzed collagen peptides are absorbed better by the body

HIF-1 regulates the expression of several genes associated with tumor progression, suggesting that 2-AR may play a role in the proliferation and invasion of liver cancer cells through the HIF-1/VEGFA signaling pathway

However, according Boukadida et al

10.1073/pnas.162369199 85 DashR

The two are studied through different primary mechanisms, and the distinction matters for anyone comparing them: Because the two proposed pathways are largely complementary rather than overlapping, some laboratories investigate both peptides within the same tissue-repair research protocols