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Bone-specific nutrients: Calcium (1000-1200mg daily from diet and supplements), vitamin D (2000-4000 IU daily achieving blood levels 40-60 ng/mL), vitamin K2 (directing calcium to bones versus soft tissues), magnesium (cofactor in bone metabolism)

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35.11, the macrophage initiates a sequence of ROS producing reactions during a burst of oxygen consumption accompanying phagocytosis

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The NLRP3 inflammasome facilitates this process by enhancing TGF- signaling through various transcription factors such as SNAIL, TWIST, and ZEB1/2 [55]