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103,104 Besides, ME2 ablation results in elevated cellular ROS levels, which activates the AMPK pathway and then stimulates TP53 to attenuate melanoma cell proliferation

Cellular stress responses: cell survival and cell death

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Arrigo, A., Casale, R., Buonocore, M., and Ciano, C

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At the forefront of these resistance mechanisms is the phenomenon of lysosomal drug sequestration, which represents a fundamental obstacle to effective chemotherapy across diverse cancer types