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Even though developing a vaccine against GPNMB positive cells seems to be beneficial, the challenge remains to only deplete cells with the highest expression of the protein but not the cells expressing it at a physiological level 63

Interestingly, a brain-specific glutamate dehydrogenase knock-out mouse was reported to show schizophrenia-like behaviours, reduced hippocampal volume, disrupted hippocampal excitatoryinhibitory balance [115]

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