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The substrate binding modes were compared among taurine to hTauT, GABA to hGAT1 (PDB: 7Y7W, GABA transporter subfamily) 35 , glycine to hGlyT1 (PDB: 8WFI, neurotransmitter amino acid transporter subfamily) 38 , and noradrenaline to hNET (PDB: 8ZPB, MAT subfamily) 39 in their occluded conformations (Supplementary Fig