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Synthetic peptides can be altered to persist longer in blood or to target specific tissues by attaching small chemical moieties or cyclizing the chain to prevent degradation

doi: 10.3389/fphar.2023.1145407 Received 16 January 2023 Accepted 27 March 2023 Published 04 April 2023 Volume 14 - 2023 Edited by Zhijie Xu, Central South University, China Reviewed by Xu-Sheng Liu, Hubei University of Medicine, China Fanhua Kang, Xiangya Changde Hospital, China Updates Copyright 2023 Zheng, Wang, Zhang, Chen, Liang, Liu, Qiu, Chen, Huang, Lu and Dai

Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, et al

doi:10.1080/15321819.2023.2182219 909. Hou H, Zhang Y, Wu H, Huang Z, Liu S, Liang H, Xu Y

The PVN normally inhibits the baroreflex via tonic GABAergic inputs (Page et al., 2011)

These findings highlight the intricate interplay between mechanosensitive and heat-sensitive channels in the PNS and CNS, suggesting Piezo2 as a potential therapeutic target for visceral pain treatment