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Open Biomarkers J

The yeast WD40 and WD40 domains are structural homologs with complete conservation of the binding site except for two residues, i.e., His31/Tyr139 in WD40 are replaced by Tyr33/Phe142 in WD40 61,62 (Supplementary Fig

Advanced glycation end-products (AGEs) represent a broad heterogeneous group of compounds formed by nonenzymatic reactions between reducing sugars or oxidized lipids and the free amino groups of proteins, amino phospholipids or nucleic acids

Transcription factor EB (TFEB) regulates the expression of autophagy and lysosomal genes, which is also phosphorylated and inhibited by mTORC1 to regulate autophagy indirectly [49] (Fig

Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade

Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK