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Ces deux derniers tant des facteurs limitant de sa synthse

Although CI-1040 in combination with sorafenib was found to have a superior antitumor effect compared to sorafenib alone in a xenograft HCC model, 207 it displayed insufficient antitumor activity in a phase 2 clinical study in solid tumors, 208 which may be due to its low exposure resulting from its fast clearance rate and poor solubility

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Glutathione defense mechanism in liver injury: insights from animal models

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