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63 By recognizing these signals, inflammasomes play a crucial role in initiating and regulating the inflammatory response in the body, particularly in response to cellular damage or microbial threats

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Mutation of clk-1 and isp-1 [42], RNAi of cyc-1 [43], and RNAi of spg-7 [39] have all also been shown to activate mitochondrial UPR

Recent studies of OA cartilage homeostasis have focused on the increase in senescent cells in articular cartilage [4,5,6] can result from mitochondrial dysfunction, excessive mechanical loading, oxidative stress, and DNA damage [7,8,9,10]