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Understanding how the nanomaterials behave in biological systems is essential for their safe and effective use

Specifically, AIF and caspase-3 play critical roles in caspase-independent and caspase-dependent apoptosis, respectively

In whole blood of people with BD in the depressive phase, the expression of genes in the ETC pathway are the most significantly altered compared to healthy controls, with 22 genes upregulated and 2 downregulated in BD [49]

Additionally, in vitro studies have demonstrated that zinc chelation inhibits AID activity, suggesting that age-associated changes in zinc homeostasis might further exacerbate the reduction in AID functionality [368]