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It is composed of three essential amino acids that attack free radicals (glycine, cysteine, and glutamic acid)

Glutathione acts by assisting the bodys machinery in the removal of harmful destructive oxygen-containing molecules

Since then, the pathophysiology due to dysregulation of intracellular iron chaperoning has become central in FRDA relative to antioxidant defense and run-down in energy metabolism

Cancer cells mitigate these ROS levels through GSH, thereby inhibiting tumor cell apoptosis

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

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