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Open 4, 6172

doi: 10.3390/ijms20205096 70 LiX.LiY.MaiJ.TaoL.QuM.LiuJ.et al

LMW-HA also induces nitric oxide synthase, upregulates matrix metalloproteinases transcription, and enhances cell migration while suppressing cell death and apoptosis in cell cultures

This finding has been reinforced by using pharmacologic inhibitors of PPP, 6-aminonicotinamide or dehydroepiandrosterone (DHEA) in both vitro and in vivo studies (61)