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You can add compounds that hit those pathways via ipamorelin, hexarelin, MK-677, etc

Based on the timing and mechanisms of resistance development, resistance to targeted therapy can be categorized into two distinct types: primary resistance, defined by pre-existing genetic alterations or clonal heterogeneity that preclude initial response, and secondary resistance, which emerges following an initial therapeutic response due to drug pressure-driven clonal selection and adaptive phenotypic changes ( Tumor heterogeneity and clonal evolution represent the fundamental biological basis of targeted therapy resistance in RCC

Its commonly used by physicians as part of pain management and trigger point injection treatments

Acta haematologica 148(2):180-197, 2025

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