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Discovery and development of MEDI7247, a novel pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, for treating hematological cancers

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Mistaken uracil substitution for thymidine can eventually result in strand breakage, unstable DNA, and defective DNA repair (163)

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Additionally, most people with chronic liver disease also have hyperhomocysteinemia, which is a sign of vitamin B deficiency and necessitates the use of B12 and B9 supplements

TABLE 1 The application of NAC in MSCs