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Cons: Time Commitment: IV therapy sessions typically last between 45-60 minutes

Mutations in genes such as PINK1 (PARK6) and PARKIN (PARK2) are the most common cause of a form of Parkinsons disease that is difficult to diagnose and one of the earliest mutation-associated genes in familial autosomal recessive inheritance of PD (Zhang et al., 2018), mutations in -Syn proteins undergo misfolding in transcription-translation to produce toxicity, and defective mitophagy further exacerbates neurotoxicity, leading to neuronal loss or damage (Wang et al., 2018)

[318 319] Through volume standardization we allow comparisons across hospitals of all sizes, while accounting for potential variations associated with patient volume, such that large volume EDs will be compared to large volume EDs, while medium and smaller volume EDs will likewise be compared to EDs of similar size