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Anti-Inflammatory Effects of Crocin and Crocetin in Rat Brain Microglial Cells

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PNS treatment was able to inhibit PI3K/Akt activation, increase IL-10 expression, significantly reduce the percentage of CD11BF4/80-labeled macrophages in DSS-induced SD rat colon tissue, and induced macrophage polarization to anti-inflammatory CD206 + M2 macrophages, thereby suppressing the intestinal inflammatory response (Lu et al., 2020)

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The number of genes with ATPase, ion transport, metal ion, or stress related annotations ranged from 69 to 99 total genes per trait (Figures 3B,C)

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