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Plasmodium berghei parasites lacking expression of gamma-glutamylcysteine synthetase (-GCS), the rate limiting enzyme in de novo synthesis of GSH, were generated through targeted gene disruption thus demonstrating, quite unexpectedly, that -GCS is not essential for blood stage development

Atienza M, Ziontz J, Cantero JL

By assessing both the strengths and limitations of these models, we highlight their contributions to uncovering disease mechanisms, identifying therapeutic targets, and facilitating novel discoveries

We review the evidence submitted by interested parties, and other evidence that CMS has on hand

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