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while respiratory viral infections cause antioxidant enzyme expression/activity inhibition associated with reduced Nrf2 nuclear localization, decreased cellular levels and reduced ARE-dependent gene transcription (Komaravelli and Casola, 2014)

Further, oxidative stress has been proven to facilitate the accumulation of strands of amyloid-beta proteins, normally present in the brain, to form amyloid plaques, which have classically been considered to be the cause and thus, the treatment target of Alzheimers disease

LoombaRSeguritanVLiWLongTKlitgordNBhattAet al

10.1016/j.tins.2012.06.001 Trends Neurosci 237 SanyalA.DeAndradeM

J Am Acad Dermatol 62(3):525527

p = 0.0037) (Supplementary Figure 1)