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Furukawa T, Fukuda A

Furthermore, microbial processes offer substantial sustainability and environmental benefits

The precise regulation of ALS pathogenetic mechanisms is still elusive, despite the abundance of identified mechanisms mediating MN degeneration and death, including neuroinflammation, glutamate excitotoxicity, altered RNA metabolism, mitochondrial dysfunction, impaired cytoskeletal integrity, altered axonal transport dynamics, OS [71, 84, 85]

These substances are highly reactive and capable of causing damage to key cellular components and organelles, including lipids, nucleic acids, and proteins, leading to the onset of senescence [53, 54]

In ruminants, this axis may extend to incorporate the rumen as a microbial reservoir: the unique physiology of rumination and eructation creates a cyclical rumen oral lung conduit through which rumen-associated taxa, including Prevotella , Ruminococcus , and Clostridium butyricum , may periodically enter the respiratory tract, as evidenced by their detection in bovine lung samples 193,194

J Appl Microbiol 102:11971208