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In light of the effectiveness of the variable MSR/MLR policy described above, we proposed to sunset the requirement at 425.110(b)(2) that CMS will terminate an ACO's participation agreement and determine that an ACO is not eligible to share in savings for that performance year if an ACO's assigned population is not at least 5,000 by the end of the performance year specified by CMS in its request for a CAP

The peptide normalized enzyme markers of muscle damage including creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase, indicating restoration of muscle cell membrane integrity and metabolic function

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Shaking the vial creates mechanical stress that can physically break these chains, a process called shearing