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In clinical practice, randomized controlled trials (RCTs) were widely conducted to evaluate the efficacy of fecal microbiota transplantation (FMT), probiotics, prebiotics, and other interventions that target the gutbone axis for osteoporosis, providing more feasibility for the integrated management of osteoporosis through the analysis of intestinal microbial data, BMD, and bone metabolic markers (48)

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Roux et al., 2015b)

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