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The Bcl-2 family member Mcl-1 can prevent apoptosis induced by multiple apoptotic triggers such as radiation and chemotherapy (Wertz et al., 2011

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PD is characterized by dopaminergic neuron loss and -synuclein aggregation, exacerbated by GSH depletion in the substantia nigra (74)

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Reduced vitamin E levels have been reported in studies on individuals affected by type 1 diabetes, and supplementation of vitamin E has been used to reduce oxidative stress [28]