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Also observed in the obese mice were increased mRNA levels of Xbp-1, Grp78 and CHOP, as these are indicators of endoplasmic reticulum stress, and are believed to be activated by obesity

doi: 10.3168/jds.2012-6005 22 BrazC

In contrast, limiting the consumption of dietary thiols, including those naturally derived from the microbiota, extended lifespan

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Therefore, the goal of next-generation mitochondrial-targeted therapies is not to eliminate mtROS entirely, but to modulate it back within a physiological window, thereby restoring redox homeostasis without causing reductive stress