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Tan JCK

The mechanism is central, not peripheral

At the pathophysiological level, two mechanisms underlie the formation of these pigmentations: (i) directly or indirectly inducing the synthesis and release of melanin by melanocytes, resulting in true pigmentation

Thus, a clinico-pathologic correlation is often necessary to ensure accurate diagnosis

The risk factors for developing melanoma are both genetic and environmental, especially the presence of multiple melanocytic nevi, dysplastic nevi and atypical mole syndrome (AMS), as the main clinical phenotypic susceptibility.49 In 1820, Norris10 described what is currently considered in a family predisposed to melanoma

It can be used to predict whether a topic label can be assigned to a given sequence, whether or not the label has been seen before