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Cell 171 , 628641.e26 (2017)

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Given that the neurological system harbors a significant abundance of PUFAs, ferroptosis induction may show promising efficacy in brain tumor treatment ( Curcumin, a polyphenol extracted from turmeric plants, upregulates ACSL4 expression and inhibits SLC7A11 and GPX4, leading to iron overload, GSH depletion, and lipid peroxidation, ultimately triggering ferroptosis in NSCLC cells (Tang et al., 2021)

Terahertz waves (ferroptosis-inhibiting EMFs, 34.5 THz) suppress ferroptosis through a direct mechanism targeting iron metabolism: they inhibit iron-transferrin binding, thereby reducing intracellular Fe 2+ accumulation, lipid peroxidation, and malondialdehyde (MDA) levels [16] [Figure 1]

PCOS patients have an increase in the oxidative stress with generation of excessive amounts of reactive oxygen species (ROS) and reduction of antioxidant capacity