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The fact that TRPM7 directly senses mechanical stimulation was, in fact, confirmed in human bone marrow mesenchymal stem cells by measuring suction-induced and hydrostatic pressure-induced membrane currents (Xiao et al., 2015) and in HEK293 cells transfected with mTRPM7 by observing pressure-induced cytosolic Ca 2+ increases (R

An open-field test reveals changes in stress behavior that are characterized by a reduction in the distance traveled by the mice in the assessment performed through the assay, which is then used to quantify the stress of conditioned fear by the animal [46-48]

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