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Consult Your Healthcare Provider: If side effects persist or worsen, consult your healthcare provider for possible dose adjustments or additional guidance

Human clinical trials examining NMN supplement use have shown measurable increases in blood NAD+ concentrations following oral administration at various doses, though optimal dosing protocols for different individuals and long-term effects continue to be studied in ongoing research

Caffeine is also found in Ceylon tea, green tea, and cocoa though in smaller amounts

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doi: 10.1016/j.abb.2013.07.002

Other studies have also shown that JAM-A knockout mice exhibit higher permeability to dextran and myeloperoxidase activity in the colon compared to wild type mice