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It is a combination of a GLP-1 agonist and an amylin agonist, explains Richard Siegel, MD, co-director of the Diabetes and Lipid Center at Tufts Medical Center and endocrinologist at Tufts Medicine Weight & Wellness Center Stoneham

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Stimuli such as shear stress, vascular endothelial growth factor (VEGF), and insulin activate kinases including protein kinase B (Akt), AMP-activated protein kinase (AMPK), calcium/calmodulin-dependent protein kinase II (CaMKII), protein kinase A (PKA), and protein kinase G (PKG), which phosphorylate Ser1177 (Fulton et al., 1999

doi: 10.3389/fmolb.2025.1638042 Received 02 June 2025 Accepted 11 August 2025 Published 04 September 2025 Volume 12 - 2025 Edited by Lidija Milkovic, Rudjer Boskovic Institute, Croatia Reviewed by Sathish Sivaprakasam, Texas Tech University Health Sciences Center, United States Jos Daz-Chvez, Instituto Nacional de Cancerologa (INCAN), Mexico Updates Copyright 2025 Gao, Jiang, Sun, An, Sun, Tang, Kang, Zhao, Li, Liu, Ji and Lian

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It also makes the treatment easier for patients