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doi: 10.1042/bj0830291 168 LeeJJIshiharaKNotomiSEfstathiouNEUetaTMaidanaDet al

A major strength of metabolomics lies in multivariate modeling

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The interaction between superoxide radical (O 2 ) and nitric oxide (NO) with proteins yields a potent oxidizing agent called peroxynitrite, the damaging effects of which extend beyond the conventional brain regions affected by AD, implying widespread oxidative damage in the brain [39]

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