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Molecular genetic differentiation between primary lung cancer and lung metastases of other tumors

Perspect 25 , 58 (2009)

2.3.1 Tcm Tcm cells are a subset of memory T cells that promote migration into lymph nodes (LNs) and quickly proliferate when they are re-exposed to antigens, producing TNF- and IL-2 and expressing CD45RO, CD62L, CD28, CD27, CCR7, CD127, CD11a, IL-18R, CXCR4, and CXCR3 but not CD45RA ( Metabolically, Tcm cells switch from glycolysis back to FAO and OXPHOS, which is regulated by AMP-activated kinase (AMPK) signaling, and their long-term survival is promoted by an increased mitochondrial spare respiratory capacity (SRC)

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