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Similar to other fenofibrate studies [43], there was a 7.9 ml/min reduction in the trial-averaged estimated glomerular filtration rate (eGFR) in the fenofibrate group

For adolescent tests, up to three offspring per litter and sex were included to control litter effects

The selected original studies were conducted in the adult population (study subjects aged 18 years)

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An interoceptive CMSI score (CMSI no pain) was calculated by subtracting the Rheum domain from the sum of the CMSI (range 0 to 128)

This finding, together with other observations 66 , 91 , suggests that Set7/9 might contribute to the FOXO3 regulation indirectly, through repression of the Sirt1 deacetylation activity (Figure 1B)