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Whereas GH insensitivity, both in humans and in transgenic mice, have only mild retardation of growth at birth as previously stated[3135], IGF-I deficiency in gestational state reveals serious postnatal growth retardation, as has been reported both in humans and in transgenic animal models of IGF-I deletion[3640]

Additional data related to this paper may be requested from the corresponding author

Peer review Peer review information Nature Reviews Endocrinology thanks Trond Michelsen, Ye Yuan and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

1d,e) was completely abrogated, in line with previous findings 25

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