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In addition, they are also expressed in the digestive, reproductive and immune system, lungs, heart, kidneys, endothelium of blood vessels and smooth muscles to a lesser extent (Izzo and Sharkey, 2010)

FOXO4-DRI effectively counteracted doxorubicin-induced cell senescence and additionally mitigated doxorubicin-induced loss of body mass and elevated levels of aspartate aminotransferase (AST), contributing to the reduction of the hepatotoxicity of the chemotherapy agent [127]

Despite encouraging progress, important questions remain regarding long-term effects, receptor pharmacology, and future applications

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These pathways are complex and involve communication between peripheral metabolic signals and central nervous system circuits

Glutamate, a key neurotransmitter involved in the pathophysiology of schizophrenia and the regulation of sleep-wake neurobiology, plays a crucial role in mediating the quality of sleep, as evidenced by the correlation between sleep disturbances and glutamate levels in specific brain regions of individuals with schizophrenia