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Balamurugan, V

Nature 435 , 220223 (2005)

thus, by inducing ROS, melatonin further inhibits proliferation and invasion [215]

Further investigation into its underlying mechanisms revealed that CP ameliorates ALD by modulating GM diversity, reducing the relative abundance of Proteobacteria and Parasutterella while increasing that of Lactobacillus and Akkermansia, restoring intestinal barrier function, elevating the expression levels of intestinal tight-junction proteins, reducing the leakage of harmful substances such as LPS from the gut, and modulating the Nrf2/Kelch-like ECH-associated protein 1 pathway to diminish hepatic oxidative stress damage and inflammatory responses [227]