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How many treatments are required and at what interval

Do not administer repeated injections of epinephrine at the same site, as the resulting vasoconstriction may cause tissue necrosis

The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction

Whereas the severity of vitamin B12 deficiency does not necessarily correlate with prognosis

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