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In a 2025 review, after 1,200 mg intravenously twice a week for six weeks, 37.5% of participants reported lighter skin compared with 18.7% in the placebo group, and the effect faded after about six months

Crucially, besides inducing membrane depolarization through 7nAChR-gated Ca2+ conductance, there is growing evidence suggesting potential metabotropic activities of this ionotropic receptor [43]

Multi-institutional collaboration reflective of the predominant geographic divisions of the United States may facilitate the creation of intentionally built datasets tasked to rigorously investigate the association between hormone levels and stone predisposition

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VY prepared the original draft