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Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia

This is the single biggest mismatch between expectation and evidence, and it's worth revisiting even after reading the section above

C., Goetz C

Iron Availability in Tissue Microenvironment: The Key Role of Ferroportin

Antioxidant Support: Glutathione is a powerful antioxidant that combats free radicals, reducing oxidative stress and preventing skin dullness

Idiopathic neuropathy When the cause of neuropathy is unknown, which affects roughly 25% of patients, a broad-spectrum approach targeting multiple mechanisms makes the most sense