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In the STEP 4 trial, participants who stopped semaglutide regained about two-thirds of the weight they had lost within one year (STEP 4 withdrawal study)

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The development of increased pigmentation is dependent on genetic factors (variability in racial groups) and hormonal factors (especially in women)

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doi: 10.1124/dmd.109.027466 64 HayashiSWatanabeJKawajiriK

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Additionally, Western blotting and immunofluorescence confirmed that ACT preserved BBB integrity by stabilizing tight junction proteins

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