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It is present ubiquitously, being most abundantly expressed in the liver (Chia et al., 2005), which promotes the binding of Janus tyrosine kinase 2 (JAK2) to a proline-rich Box 1 region located in the proximal intracellular portion of the GHR (Fowden, Since 1966, more than 250 patients with genetic GHI have been identified worldwide (Lupu et al., 2001

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