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Plasma levodopa metabolites, DOPAC and dopamine, showed a statistically non-significant upward trend over 3 days in the KD group compared to the standard diet group

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Changes have also been noted in higher brain centres, including reduced connectivity between the thalamus and cortex 129 and structural changes, such as a greater reduction in thalamic grey matter volume, in patients with painful diabetic neuropathy compared with those with painless diabetic neuropathy 130