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Symptomatic models of Parkinsons disease and L-DOPA-Induced dyskinesia in Non-human Primates

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The X-ray-derived data of small molecular fragments in complex with TGR used in this study to design the compounds here described are available in the PDB under accession codes 6FTC, 6FMU, 6FMZ, 6FP4, 2X99, 2X8G, 2X8H, 6ZST, 6ZP3, 6ZLP, 6ZLB, 7B02, 7NPX, 2V6O, 6RTJ, 6RTO, 6RTM, and 3H4K

And if youre in a flare now, its reasonable to reach out for care rather than waiting

Kelland LR, Barnard CF, Evans IG, Murrer BA, Theobald BR, Wyer SB, Goddard PM, Jones M, Valenti M and Bryant A

3 In addition, a number of other mechanisms, like increased GR expression, defective histone acetylation, and involvement of immune cells have also been demonstrated