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Since all other reagents are provided in excess, the GPx activity is rate-limiting

Liposomal forms are less affected by gastric transit time, but the principle still applies

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Its small size confers favorable physicochemical properties for solubility, stability, and intranasal or subcutaneous delivery, but also raises questions about specificity that are common to short peptides in vivo proteolytic stability, off-target binding, and minimum receptor recognition motif identification all require additional characterization that the published literature does not yet fully provide

doi:10.2165/00023210-200216110-00002