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The hydroxylation at the asparaginyl residue blocks the interaction of the alpha subunits with coactivators and thus results in the inactivation of HIF

GSEA analysis revealed a significant enrichment of a NRF2 stress-response signature 31

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AA: amino acid AOPP: advanced oxidized protein products ASR: absolute synthesis rate FSR: fractional synthesis rate GSH: glutathione ROS: reactive oxygen species References Richmond S, Goldsmith JP 2006 Air or 100% oxygen in neonatal resuscitation

VIC also stimulates iron absorption at the intestinal level by reducing Fe 3+ to Fe 2+ , making it more stable and contributing to anemia management [2,8,10]