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l-carnitine has been frequently recommended as a supplement to increase physical activity in obese individuals due to its role in fatty acid metabolism, immune disorders, and in maintaining the mitochondrial acetyl-CoA/CoA ratio

Numerosissimi studi, sia di natura sperimentale che clinica, hanno tuttavia sottolineato l'incapacit della supplementazione con L-Carnitina di indurre un miglioramento apprezzabile e statisticamente significativo della composizione corporea ed in particolare una riduzione della massa grassa

Free Report Albrecht DS, et al

However, while specific populations (such as subjects with documented zinc deficiency or at risk of severe malnutrition) appear to greatly benefit from zinc supplementation in terms of thyroid function, the role of zinc supplementation in the general population as a protective factor for thyroid disorders is still not fully established [62]

Patients with classic PCOS phenotype show alterations in the follicular fluid intermediate metabolites and the cumulus cells have an increase in oxidative stress, which causes the alteration of processes of follicular growth and oocyte development, causing the reduction in the pregnancy rate [61]